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Can a MSI GeForce RTX 3080 GAMING X TRIO 10G run Llama 3.2 3B?

Yes — Runs well

Fits in 10 GB of VRAM (needs ~4 GB) — runs fully on the GPU at Q4_K_M.

Your VRAM
10 GB
Needs (est.)
4 GB
Quantization
Q4_K_M